References

Below is a list of key references.

• Boycheva S, Chkodrov G, Ivanov I. (2002) Codon pairs in the genome of Echerichia coli. Bioinf. 19(8):987-998.
  
• Kane JF. (1995) Effects of rare codon clusters on high-level expression of heterologous proteins in Escherichia coli. Curr. Opin. Biotechnol. 6:494-500.
  
• Marintchev A, Wagner G. (2004) Translation initiation: structures, mechanisms and evolution. Q. Rev. Biophys. 37:197-284.
  
• Pfitzinger H, Guillernaut P, Weil JH, Pillay DTN. (1987) Adjustment of the tRNA population to the codon usage in chloroplasts. Nucleic Acid Res. 15(4):1377-1386.
  
• Sharp MP, Li WH. (1987) Codon Adaptation Index – a measure of directional synonymous codon usage bias, and its potential applications. Nucleic Acid Res. 15:1281-1295.
  
• Tuller T, Waldman YY, Kupiec M, Ruppin E. (2010) Translation efficiency is determined by both codon bias and folding energy. Proc. Natl Acad. Sci. 107:3645-3650.
  
• Welch M, Villalobos A, Gustafsson C, Minshull J. (2011) Designing Genes for Successful Protein Expression. Methods Enzymol. 498:43-66.PMID: 21601673
  

Acknowledgements

Bioinformations

Collaborators

Technologies

Special Thanks